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Valacyclovir and prednisolone answer to be... [otol neurotol. 2007] - pubmed - ncbi
AbstractOBJECTIVE:

To investigate results of valacyclovir and prednisolone in comparison with those of placebo and prednisolone for your treatments for Bell's palsy, excluding zoster sine herpete.

Prospective, multicenter, randomized placebo-controlled study.

Six academic tertiary referral centers.

Ultimately, 221 patients with Bell's palsy who were treated within a week on the onset. Serological and polymerase squence of events examinations were performed to distinguish Bell's palsy from zoster sine herpete.

The patients were cured with either valacyclovir (dosage, 1,000 mg/d for five days) plus prednisolone (VP [n = 114]) or placebo plus prednisolone (PP [n = 107]) administered orally.

Recovery from the palsy was thought as a score over 36 using Yanagihara 40-point scoring system without facial contracture or synkinesis. The patients were accompanied until complete recovery occurred or even for 6 or more months in the event which has a poor prognosis.

The overall rate of patient recovery amongst those treated with VP (96. 5%) was significantly better (p < 0. 05) than the rate among those treated with PP (89. 7%). The rate of patient recovery was also analyzed by classifying the initial severity of facial palsy. In cases of complete or severe palsy, the rates of patients treated with VP and PP who recovered were 95. buy naltrexone without a prescription 7% (n = 92) and 86. 6% (n = 82), respectively; the recovery rate for treatment with VP was significantly better than that with PP (p < 0. 05).

The valacyclovir and prednisolone therapy was better for treating Bell's palsy, excluding zoster sine herpete, compared to the conventional prednisolone therapy. In our knowledge, this can be the first controlled study of an antiviral agent inside treatment of an adequate variety of Bell's palsy cases based on an etiologic background.